Txog Platelet Rich Plasma (PRP)
Platelet-nplua nuj ntshav plasma (PRP) muaj qhov sib piv cov nqi kho mob rau cov qia hlwb thiab tam sim no yog ib qho kev cog lus zoo tshaj plaws hauv cov tshuaj kho dua tshiab.Nws tau siv ntau dua hauv kev kho mob sib txawv, suav nrog tshuaj pleev ib ce, tshuaj orthopedics, tshuaj kis las thiab phais.
Xyoo 1842, cov qauv uas tsis yog cov qe ntshav liab thiab dawb tau pom hauv cov ntshav, uas ua rau nws xav tsis thoob.Julius Bizozero yog thawj lub npe rau cov qauv platelet tshiab "le pistrine del sangue" - platelets.Xyoo 1882, nws tau piav qhia txog lub luag haujlwm ntawm platelets hauv coagulation hauv vitro thiab lawv txoj kev koom tes hauv etiology ntawm thrombosis hauv vivo.Nws kuj pom tau tias cov hlab ntsha phab ntsa inhibit platelet adhesion.Wright tau ua qhov kev vam meej ntxiv hauv kev txhim kho cov txheej txheem kho dua tshiab nrog nws qhov kev tshawb pom ntawm macrokaryocytes, uas yog precursors rau platelets.Thaum ntxov xyoo 1940, cov kws kho mob tau siv embryonic "extracts" tsim los ntawm kev loj hlob thiab cytokines los txhawb kev kho qhov txhab.Kev kho mob sai thiab ua tau zoo yog qhov tseem ceeb rau kev ua tiav ntawm cov txheej txheem phais.Yog li ntawd, Eugen Cronkite li al.qhia txog kev sib xyaw ntawm thrombin thiab fibrin hauv daim tawv nqaij grafts.Los ntawm kev siv cov khoom saum toj no, kev ruaj khov thiab ruaj khov ntawm lub ntsej muag yog ua kom ntseeg tau, uas ua lub luag haujlwm tseem ceeb hauv hom kev phais no.
Thaum pib ntawm lub xyoo pua 20th, cov kws kho mob tau lees paub qhov yuav tsum tau ceev ceev los qhia platelet transfusions los kho thrombocytopenia.Qhov no tau ua rau kev txhim kho hauv cov txheej txheem platelet concentrate.Ntxiv nrog rau platelet concentrates tuaj yeem tiv thaiv los ntshav hauv cov neeg mob.Thaum lub sijhawm, cov kws kho mob thiab cov kws kuaj ntshav kuaj ntshav tau sim npaj platelet concentrates rau kev hloov pauv.Cov txheej txheem kom tau txais cov concentrates tau tsim sai heev thiab tau txhim kho zoo, vim tias cov phaj sib cais sai sai poob lawv txoj kev muaj peev xwm thiab yuav tsum tau khaws cia ntawm 4 ° C thiab siv tsis pub dhau 24 teev.
Cov ntaub ntawv thiab cov txheej txheem
Hauv xyoo 1920, citrate tau siv los ua cov tshuaj tiv thaiv kab mob kom tau txais platelet concentrates.Kev nce qib hauv kev npaj cov platelet concentrates tau nrawm dua hauv xyoo 1950 thiab 1960s thaum cov ntim cov ntshav hloov pauv tau tsim.Lo lus "platelet-nplua nuj plasma" yog thawj zaug siv los ntawm Kingsley li al.Hauv xyoo 1954, xa mus rau cov qauv platelet concentrates siv rau kev hloov ntshav.Thawj lub txhab nyiaj ntshav PRP cov qauv tau tshwm sim hauv xyoo 1960 thiab tau nrov hauv xyoo 1970.Thaum xyoo 1950 thiab 1960s, "EDTA platelet packs" tau siv.Cov txheej txheem muaj ib lub hnab yas nrog EDTA cov ntshav uas tso cai rau cov platelets kom muaj zog los ntawm centrifugation, uas tseem raug tshem tawm hauv me me ntawm cov ntshav tom qab phais.
Kev tshwm sim
Nws tau kwv yees tias qhov tseem ceeb ntawm kev loj hlob (GFs) yog cov sib txuas ntxiv ntawm PRP uas tau zais los ntawm cov platelets thiab koom nrog hauv nws qhov kev ua.Qhov kev xav no tau lees paub hauv xyoo 1980s.Nws hloov tawm tias platelets tso tawm bioactive molecules (GFs) los kho cov ntaub so ntswg puas, xws li daim tawv nqaij rwj.Txog niaj hnub no, ob peb txoj kev tshawb fawb tshawb nrhiav qhov teeb meem no tau ua.Ib qho ntawm cov kev kawm feem ntau hauv daim teb no yog kev sib xyaw ntawm PRP thiab hyaluronic acid.Epidermal growth factor (EGF) tau tshawb pom los ntawm Cohen xyoo 1962. Cov GFs tom ntej yog platelet-derived growth factor (PDGF) hauv xyoo 1974 thiab vascular endothelial growth factor (VEGF) xyoo 1989.
Zuag qhia tag nrho, kev nce qib hauv cov tshuaj kuj tau ua rau muaj kev nce qib sai hauv cov ntawv thov platelet.Nyob rau hauv 1972, Matras thawj zaug siv platelets ua ib lub sealant los tsim cov ntshav homeostasis thaum phais.Tsis tas li ntawd, xyoo 1975, Oon thiab Hobbs yog thawj tus kws tshawb fawb siv PRP hauv kev kho dua tshiab.Xyoo 1987, Ferrari et al thawj zaug siv platelet-nplua nuj plasma raws li qhov chaw ntawm cov ntshav ntshav hauv kev phais mob plawv, yog li txo qis cov ntshav tsis txaus, cov ntshav tsis zoo ntawm cov hlab ntsws peripheral, thiab tom qab siv cov khoom siv ntshav.
Xyoo 1986, Knighton et al.yog thawj tus kws tshawb fawb los piav qhia txog cov txheej txheem platelet enrichment thiab hu ua autologous platelet-derived wound healing factor (PDWHF).Txij li thaum tsim cov txheej txheem, cov txheej txheem tau nce ntxiv hauv cov tshuaj kho kom zoo nkauj.PRP tau siv nyob rau hauv cov tshuaj regenerative txij li thaum xyoo 1980s.
Ntxiv rau kev phais dav dav thiab kev phais plawv, kev phais maxillofacial yog lwm qhov chaw uas PRP tau nrov nyob rau xyoo 1990.PRP tau siv los txhim kho graft bonding hauv mandibular reconstruction.PRP kuj tau pib siv rau hauv kev kho hniav thiab tau siv txij li xyoo 1990s los txhim kho kev sib raug zoo ntawm kev cog hniav thiab txhawb kev tsim cov pob txha.Tsis tas li ntawd, cov kua nplaum fibrin yog cov khoom siv paub zoo uas tau qhia thaum lub sijhawm.Kev siv PRP hauv kev kho hniav tau tsim kho ntxiv nrog kev tsim cov platelet-nplua nuj fibrin (PRF), platelet mloog zoo uas tsis tas yuav ntxiv cov tshuaj tiv thaiv coagulants, los ntawm Choukroun.
PRF tau dhau los ua neeg nyiam nyob rau xyoo 2000s thaum ntxov, nrog rau kev siv ntau ntxiv hauv cov txheej txheem kho hniav, suav nrog kev tsim kho cov ntaub so ntswg hyperplastic gingival thiab periodontal defects, palatal qhov txhab kaw, gingival recession kev kho mob, thiab lub tes tsho extraction.
Sib tham
Anitua xyoo 1999 tau piav qhia txog kev siv PRP los txhawb kev tsim cov pob txha thaum lub sij hawm hloov ntshav plasma.Tom qab soj ntsuam cov txiaj ntsig zoo ntawm kev kho mob, cov kws tshawb fawb tau tshawb xyuas qhov tshwm sim ntxiv.Nws cov ntaub ntawv tom ntej tau tshaj tawm txog qhov cuam tshuam ntawm cov ntshav no rau ntawm daim tawv nqaij mob ntev, kev cog hniav, kho cov leeg, thiab kev raug mob orthopedic.Ntau cov tshuaj uas qhib PRP, xws li calcium chloride thiab bovine thrombin, tau siv txij li xyoo 2000.
Vim nws cov khoom zoo heev, PRP yog siv hauv orthopaedics.Cov txiaj ntsig ntawm thawj qhov kev tshawb fawb tob txog qhov cuam tshuam ntawm kev loj hlob ntawm tib neeg cov ntaub so ntswg tau luam tawm xyoo 2005. PRP txoj kev kho tam sim no yog siv los kho cov kab mob degenerative thiab txhawb kev kho cov leeg, ligaments, cov leeg thiab pob txha mos.Kev tshawb fawb qhia tias qhov tseem ceeb ntawm cov txheej txheem hauv orthopedics kuj tseem cuam tshuam nrog kev siv PRP nquag los ntawm cov hnub qub ncaws pob.Hauv xyoo 2009, ib qho kev sim tsiaj tshawb fawb tau luam tawm uas tau lees paub qhov kev xav tias PRP concentrates txhim kho cov leeg nqaij zoo.Lub hauv paus txheej txheem ntawm PRP kev txiav txim hauv daim tawv nqaij tam sim no yog qhov kev tshawb fawb ntawm kev tshawb fawb hnyav.
PRP tau siv tau zoo hauv tshuaj pleev ib ce dermatology txij li xyoo 2010 los yog ntxov dua.Tom qab txhaj tshuaj PRP, daim tawv nqaij zoo li hluas dua thiab hydration, yoog raws thiab xim zoo tuaj.PRP kuj tseem siv los txhim kho plaub hau kev loj hlob.Muaj ob hom PRP tam sim no siv rau kev kho plaub hau - tsis muaj platelet-nplua nuj plasma (A-PRP) thiab active platelet-nplua nuj plasma (AA-PRP).Txawm li cas los xij, Gentile et al.pom tau hais tias cov plaub hau ceev thiab cov plaub hau suav tsis tuaj yeem txhim kho los ntawm kev txhaj tshuaj A-PRP.Tsis tas li ntawd, nws tau raug pov thawj tias siv PRP kev kho mob ua ntej kev hloov cov plaub hau tuaj yeem txhim kho cov plaub hau kev loj hlob thiab cov plaub hau ntom.Tsis tas li ntawd, xyoo 2009, cov kev tshawb fawb pom tau hais tias kev siv cov khoom sib xyaw ntawm PRP thiab cov rog tuaj yeem txhim kho kev noj qab haus huv thiab kev muaj sia nyob, uas tuaj yeem txhim kho cov txiaj ntsig ntawm kev phais yas.
Qhov kev tshawb pom tshiab los ntawm Cosmetic Dermatology qhia tias kev sib xyaw ntawm PRP thiab CO2 laser kho tuaj yeem txo cov pob txuv nti ntau dua.Ib yam li ntawd, PRP thiab microneedling ua rau muaj kev sib koom ua ke collagen ntau dua hauv daim tawv nqaij dua li PRP ib leeg.Keeb kwm ntawm PRP tsis luv, thiab cov kev tshawb pom muaj feem xyuam rau cov ntshav no tseem ceeb.Cov kws kho mob thiab cov kws tshawb fawb tau nquag tshawb nrhiav cov kev kho mob tshiab.Raws li txhais tau tias, PRP tau siv ntau yam tshuaj, suav nrog gynecology, urology, thiab ophthalmology.
Keeb kwm ntawm PRP yog tsawg kawg yog 70 xyoo.Yog li ntawd, txoj kev tsim tau zoo thiab tuaj yeem siv dav hauv tshuaj.
(Cov ntsiab lus ntawm tsab xov xwm no tau luam tawm dua, thiab peb tsis muab ib qho kev qhia lossis kev lees paub rau qhov raug, kev ntseeg tau lossis ua tiav ntawm cov ntsiab lus muaj nyob rau hauv tsab xov xwm no, thiab tsis muaj lub luag haujlwm rau cov kev xav ntawm tsab xov xwm no, thov nkag siab.)
Post lub sij hawm: Lub Xya hli ntuj-28-2022