Androgenic alopecia (AGA), hom plaub hau poob ntau tshaj plaws, yog ib qho kev loj hlob ntawm cov plaub hau tsis zoo uas pib thaum hluas los yog thaum hluas.Feem ntau ntawm cov txiv neej hauv kuv lub tebchaws yog li 21.3%, thiab cov pojniam feem ntau yog li 6.0%.Txawm hais tias qee tus kws tshawb fawb tau npaj cov lus qhia rau kev kuaj mob thiab kev kho mob ntawm androgenetic alopecia hauv Suav teb yav dhau los, lawv tsuas yog tsom mus rau kev kuaj mob thiab kev kho mob ntawm AGA, thiab lwm yam kev kho mob tsis tshua muaj.Nyob rau hauv xyoo tas los no, nrog rau qhov tseem ceeb ntawm kev kho AGA, qee qhov kev kho tshiab tau tshwm sim.
Etiology thiab Pathogenesis
AGA yog ib hom kab mob uas tau tshwm sim los ntawm polygenic recessive disorder.Cov kev tshawb fawb txog kev kis kab mob hauv tsev qhia tau tias 53.3%-63.9% ntawm cov neeg mob AGA muaj keeb kwm hauv tsev neeg, thiab cov kab ntawm leej txiv yog qhov ntau dua li cov niam txiv.Tam sim no tag nrho-genome sequencing thiab daim ntawv qhia kev tshawb fawb tau txheeb xyuas ob peb cov noob caj noob ces, tab sis lawv cov kab mob pathogenic tseem tsis tau txheeb xyuas.Kev tshawb fawb tam sim no qhia tau hais tias androgens ua lub luag haujlwm txiav txim siab hauv cov kab mob ntawm AGA;Lwm yam xws li mob nyob ib ncig ntawm cov hauv paus plaub hau, nce lub neej siab, nruj thiab kev ntxhov siab, thiab kev noj zaub mov tsis zoo tuaj yeem ua rau cov tsos mob ntawm AGA hnyav dua.Androgens nyob rau hauv cov txiv neej feem ntau yog los ntawm testosterone secreted los ntawm testes;androgens nyob rau hauv cov poj niam feem ntau yog los ntawm cov synthesis ntawm adrenal cortex thiab ib tug me me ntawm secretion los ntawm zes qe menyuam, androgen feem ntau yog androstenediol, uas yuav metabolized rau hauv testosterone thiab dihydrotestosterone.Txawm hais tias androgens yog ib qho tseem ceeb ntawm cov kab mob ntawm AGA, cov theem androgen circulating nyob rau hauv yuav luag tag nrho cov neeg mob AGA raug tswj kom zoo li qub.Cov kev tshawb fawb pom tau hais tias cov nyhuv ntawm androgens ntawm cov plaub hau follicles raug nce vim muaj zog androgen receptor gene qhia thiab / los yog nce kev qhia ntawm hom II 5α reductase noob hauv cov hauv paus plaub hau hauv thaj tsam alopecia.Rau AGA, cov kab mob dermal ntawm cov hauv paus plaub hau muaj kev cuam tshuam tshwj xeeb hom II 5α reductase, uas tuaj yeem hloov pauv cov androgen testosterone mus rau thaj chaw hauv cov ntshav mus rau dihydrotestosterone los ntawm kev khi rau intracellular androgen receptor.Pib ib tug series ntawm cov tshuaj tiv thaiv ua rau kev loj hlob me me ntawm cov hauv paus plaub hau thiab cov plaub hau poob rau baldness.
Clinical Manifestations thiab kho cov lus pom zoo
AGA yog ib hom kab mob alopecia uas tsis tshua muaj tshwm sim thaum lub hnub nyoog hluas thiab yog tus cwj pwm los ntawm kev nce zuj zus ntawm cov plaub hau txoj kab uas hla, poob ntawm cov plaub hau ntom ntom, thiab alopecia kom txog thaum sib txawv ntawm qhov tawv nqaij, feem ntau nrog cov tsos mob ntawm cov tawv taub hau roj secretion.
Daim ntawv thov PRP
Cov platelet concentration yog sib npaug rau cov concentration ntawm 4-6 npaug ntawm platelet concentration hauv tag nrho cov ntshav.Thaum PRP tau qhib lawm, α granules hauv platelets yuav tso tawm ntau yam kev loj hlob, suav nrog platelet-derived kev loj hlob yam, hloov kev loj hlob factor-β, insulin-zoo li kev loj hlob factor, epidermal kev loj hlob factor thiab vascular endothelial kev loj hlob, thiab lwm yam. ntawm kev txhawb cov plaub hau follicle loj hlob, tab sis cov txheej txheem tshwj xeeb ntawm kev ua tsis tau meej meej.Kev siv yog txhaj tshuaj PRP hauv zos rau hauv cov dermis txheej ntawm tawv taub hau hauv thaj chaw alopecia, ib hlis ib zaug, thiab kev txhaj tshuaj tas li 3 mus rau 6 zaug tuaj yeem pom muaj qee yam tshwm sim.Txawm hais tias ntau yam kev tshawb fawb soj ntsuam hauv tsev thiab txawv teb chaws tau lees paub ua ntej tias PRP muaj qee yam cuam tshuam rau AGA, tsis muaj tus qauv zoo rau kev npaj PRP, yog li qhov txiaj ntsig zoo ntawm PRP kev kho mob tsis zoo li qub, thiab nws tuaj yeem siv los ua ib qho kev pabcuam. txhais tau tias rau kev kho AGA nyob rau theem no.
(Cov ntsiab lus ntawm tsab xov xwm no tau luam tawm dua, thiab peb tsis muab ib qho kev qhia lossis kev lees paub rau qhov raug, kev ntseeg tau lossis ua tiav ntawm cov ntsiab lus muaj nyob rau hauv tsab xov xwm no, thiab tsis muaj lub luag haujlwm rau cov kev xav ntawm tsab xov xwm no, thov nkag siab.)
Post lub sij hawm: Aug-02-2022