PRP ua los ntawm degranulation ntawm alpha granules los ntawm platelets, uas muaj ntau yam kev loj hlob.Active secretion ntawm cov kev loj hlob yam yog pib los ntawm cov ntshav coagulation txheej txheem thiab pib nyob rau hauv 10 feeb ntawm coagulation.Ntau tshaj 95% ntawm cov khoom ua ntej kev sib txuas ua ke tau zais hauv 1 teev.Yog li ntawd, PRP yuav tsum tau npaj nyob rau hauv lub xeev anticoagulant thiab yuav tsum tau siv nyob rau hauv grafts, flaps, los yog qhov txhab nyob rau hauv 10 feeb ntawm cov ntshav txhaws.Cov kev tshawb fawb uas tsis siv cov ntshav anticoagulated tag nrho tsis yog qhov tseeb PRP cov kev tshawb fawb thiab ua yuam kev.
Raws li cov platelets tau qhib los ntawm cov txheej txheem ntawm cov txheej txheem, cov txheej txheem loj hlob yog secreted los ntawm cov cell los ntawm cov cell membrane.Hauv cov txheej txheem no, alpha particles fuse rau platelet cell membranes, thiab cov protein loj hlob tuaj ua tiav lub xeev bioactive los ntawm kev ntxiv histone thiab carbohydrate sab chains rau cov proteins.Yog li, platelets puas lossis inactivated los ntawm PRP kev kho mob tsis tso cai rau bioactive kev loj hlob thiab tej zaum yuav ua rau poob siab.Cov txheej txheem kev loj hlob uas zais cia tam sim ntawd mus rau sab nrauv ntawm daim nyias nyias ntawm cov hlwb hauv kev cog qoob loo, nrov plig plawg, los yog qhov txhab ntawm transmembrane receptors.
Cov kev tshawb fawb tau pom tias cov neeg laus mesenchymal qia hlwb, osteoblasts, fibroblasts, endothelial hlwb, thiab epidermal hlwb qhia cell membrane receptors rau kev loj hlob yam hauv PRP.Cov transmembrane receptors nyob rau hauv lem induce lub activation ntawm endogenous internal signaling proteins uas ua rau cov kev qhia (xauv) ntawm ib txwm cellular gene sequences, xws li cell proliferation, matrix tsim, osteoid tsim, collagen synthesis, thiab lwm yam.
Qhov tseem ceeb ntawm qhov kev paub no yog tias PRP kev loj hlob yam tsis tau nkag mus rau hauv lub cell los yog nws cov nucleus, lawv tsis yog mutagenic, lawv tsuas yog ua kom lub zog ntawm kev kho kom zoo.Yog li ntawd, PRP tsis muaj peev xwm los tsim cov qog nqaij hlav.
Tom qab thawj zaug tawg ntawm PRP-txuas nrog kev loj hlob yam, platelets synthesize thiab secrete ntxiv kev loj hlob yam tseem ceeb rau 7 hnub ntawm lawv lub neej.Thaum platelets depleted thiab tuag, macrophages uas ncav cuag thaj av los ntawm platelet-stimulated cov hlab ntsha loj hlob mus rau hauv lub luag hauj lwm ntawm lub qhov txhab kho regulator los ntawm secreting ib co ntawm cov tib txoj kev loj hlob yam tseem ceeb thiab lwm yam.Yog li, tus naj npawb ntawm cov platelets nyob rau hauv graft, qhov txhab, los yog cov ntshav txhaws nyob rau hauv lub flap txiav txim seb lub qhov txhab kho sai npaum li cas.PRP tsuas yog ntxiv rau tus lej ntawd.
Muaj pes tsawg platelets txaus?
Cov kev tshawb fawb tau pom tias kev loj hlob thiab kev sib txawv ntawm cov neeg laus MSCS ncaj qha cuam tshuam nrog platelet concentration.Lawv tau pom cov koob tshuaj tiv thaiv kab mob, uas qhia tau hais tias cov lus teb ntawm cellular txaus rau platelet concentration thawj zaug pib thaum plaub mus rau tsib zaug ntawm cov platelet suav hauv paus.Ib txoj kev tshawb fawb zoo sib xws tau pom tias nce platelet concentration kuj txhim kho fibroblast proliferation thiab hom I collagen ntau lawm, thiab hais tias feem ntau ntawm cov lus teb yog PH-nyob, nrog cov lus teb zoo tshaj plaws tshwm sim ntawm ntau acidic pH.
Cov kev tshawb fawb no tsis tsuas yog qhia txog qhov xav tau ntawm cov cuab yeej siv kom pom cov platelets txaus, tab sis kuj piav qhia txog kev txhim kho cov pob txha rov tsim dua tshiab thiab txhim kho cov ntaub so ntswg zoo cuam tshuam nrog PRP.
Txij li thaum tib neeg feem ntau muaj cov lej platelet suav ntawm 200,000 ± 75,000 ib μl, PRP platelet suav ntawm 1 lab ib μl ntsuas hauv tus qauv 6-ml aliquots tau dhau los ua tus qauv rau "kev kho mob PRP."Qhov tseem ceeb, cov kev tshawb fawb tau pom tias qhov platelet concentration tau ua tiav thaum qib kev kho mob mus txog, yog li tso tawm qhov kev loj hlob.
(Cov ntsiab lus ntawm tsab xov xwm no tau luam tawm dua, thiab peb tsis muab ib qho kev qhia lossis kev lees paub rau qhov raug, kev ntseeg tau lossis ua tiav ntawm cov ntsiab lus muaj nyob rau hauv tsab xov xwm no, thiab tsis muaj lub luag haujlwm rau cov kev xav ntawm tsab xov xwm no, thov nkag siab.)
Post lub sij hawm: Sep-01-2022