Platelets, raws li cov xov tooj ntawm tes los ntawm cov pob txha pob txha megakaryocytes, yog tus cwj pwm los ntawm qhov tsis muaj nuclei.Txhua platelet muaj peb yam hais, uas yog α Granules, lub cev ntom ntom thiab lysosomes nrog ntau qhov sib txawv.Xws li α Cov granules yog nplua nuj nyob rau hauv ntau tshaj 300 proteins sib txawv, xws li vascular endothelial activating factor, leukocyte chemotactic factor, activating factor, cov ntaub so ntswg kho muaj feem xyuam rau txoj kev loj hlob thiab antibacterial peptide, uas yog koom nyob rau hauv ntau yam physiological thiab pathological dab, xws li qhov txhab kho. , angiogenesis thiab tiv thaiv kab mob tiv thaiv kab mob.
Lub cev ntom ntom muaj cov ntsiab lus siab ntawm adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2+ thiab 5-hydroxytryptamine.Lysosomes muaj ntau yam qab zib proteases, xws li glycosidases, proteases, cationic proteins thiab cov proteins uas muaj cov kab mob bactericidal.Cov GF no raug tso tawm rau hauv cov ntshav tom qab platelet ua haujlwm.
GF ua rau cov tshuaj tiv thaiv cascade los ntawm kev khi nrog ntau hom cell membrane receptors, thiab ua haujlwm tshwj xeeb hauv cov txheej txheem ntawm cov ntaub so ntswg.Tam sim no, GF tau kawm ntau tshaj plaws yog platelet derived growth factor (PDGF) thiab transforming growth factor (TGF- β （TGF- β), Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), Cov ntaub so ntswg sib txuas (CTGF) thiab insulin zoo li kev loj hlob zoo tshaj plaws-1 (IGF-1). Cov GFs no pab kho cov leeg nqaij, leeg, ligament thiab lwm cov ntaub so ntswg los ntawm kev txhawb nqa cell proliferation thiab sib txawv, angiogenesis thiab lwm yam txheej txheem, thiab tom qab ntawd ua si sib xws. lub luag haujlwm.
Kev thov ntawm PRP hauv Vitiligo
Vitiligo, raws li ib tug tshwm sim ntawm autoimmune kab mob, raws li zoo raws li ib tug ntim impaired kab mob ntawm daim tawv nqaij, muaj kev cuam tshuam tsis zoo rau lub hlwb ntawm cov neeg mob thiab cuam tshuam rau lub neej zoo ntawm cov neeg mob.Raws li qhov tshwm sim, qhov tshwm sim ntawm vitiligo yog tshwm sim los ntawm kev sib cuam tshuam ntawm caj ces yam thiab ib puag ncig yam, uas ua rau cov tawv nqaij melanocytes raug tawm tsam thiab puas los ntawm autoimmune system.Tam sim no, txawm hais tias muaj ntau yam kev kho mob rau vitiligo, lawv cov kev ua tau zoo feem ntau tsis zoo, thiab ntau cov kev kho mob tsis muaj pov thawj ntawm cov tshuaj pov thawj.Nyob rau hauv xyoo tas los no, nrog rau kev tshawb nrhiav txuas ntxiv ntawm cov kab mob ntawm vitiligo, qee txoj kev kho tshiab tau siv tas li.Raws li ib txoj hauv kev zoo los kho vitiligo, PRP tau siv tas li.
Tam sim no, 308 nm excimer laser thiab 311 nm nqaim band ultraviolet (NB-UVB) thiab lwm yam thev naus laus zis thev naus laus zis tau lees paub ntau ntxiv rau lawv cov txiaj ntsig hauv cov neeg mob vitiligo.Tam sim no, kev siv autologous PRP subcutaneous microneedle txhaj tshuaj ua ke nrog phototherapy nyob rau hauv cov neeg mob uas ruaj khov vitiligo tau ua tau zoo.Abdelghani et al.pom nyob rau hauv lawv cov kev tshawb fawb uas autologous PRP subcutaneous microneedle txhaj tshuaj ua ke nrog NB-UVB phototherapy tuaj yeem txo lub sijhawm kho tag nrho ntawm cov neeg mob vitiligo.
Khatab et al.kho cov neeg mob uas tsis muaj segmental vitiligo ruaj khov nrog 308 nm excimer laser thiab PRP, thiab ua tiav cov txiaj ntsig zoo.Nws tau pom tias kev sib xyaw ua ke ntawm ob tuaj yeem txhim kho leucoplakia recolor tus nqi, txo lub sijhawm kho, thiab zam qhov tsis zoo ntawm kev siv mus sij hawm ntev ntawm 308 nm excimer laser irradiation.Cov kev tshawb fawb no qhia tias PRP ua ke nrog kev kho mob yog ib txoj hauv kev zoo rau kev kho mob vitiligo.
Txawm li cas los xij, Ibrahim thiab lwm yam kev tshawb fawb kuj qhia tias PRP ib leeg tsis zoo rau kev kho mob vitiligo.Kadry et al.tau ua kev tshawb fawb randomized ntawm kev kho mob vitiligo nrog PRP ua ke nrog carbon dioxide dot matrix laser, thiab pom tias PRP ua ke nrog carbon dioxide dot matrix laser thiab PRP ib leeg tau ua tiav cov xim zoo nkauj.Ntawm lawv, PRP ua ke nrog cov pa roj carbon dioxide dot matrix laser muaj cov nyhuv xim zoo tshaj plaws, thiab PRP ib leeg tau ua tiav cov xim me me hauv cov leukoplakia.Cov xim luam tawm ntawm PRP ib leeg yog qhov zoo dua li cov pa roj carbon dioxide dot matrix laser ib leeg hauv kev kho mob vitiligo.
Kev Ua Haujlwm Ua Ke nrog PRP hauv Kev Kho Mob Vitiligo
Vitiligo yog ib hom kab mob pigment disorder uas tshwm sim los ntawm depigmentation.Cov kev kho mob ib txwm muaj xws li kev kho tshuaj, kev kho mob lossis kev phais, lossis kev sib xyaw ntawm ntau txoj kev kho mob.Rau cov neeg mob uas muaj kev ruaj khov vitiligo thiab cov nyhuv tsis zoo ntawm kev kho cov pa, kev kho phais tuaj yeem yog thawj qhov kev cuam tshuam.
Garg et al.siv PRP raws li tus neeg sawv cev ncua kev kawm ntawv ntawm cov kab mob epidermal, thiab siv Er: YAG laser los zom cov pob dawb, uas ua tiav cov txiaj ntsig zoo hauv kev kho mob ntawm cov neeg mob vitiligo ruaj khov.Nyob rau hauv txoj kev tshawb no, 10 cov neeg mob uas ruaj khov vitiligo tau cuv npe thiab 20 qhov txhab tau txais.Hauv 20 qhov txhab, 12 qhov txhab (60%) pom tias ua tiav cov xim rov qab, 2 qhov txhab (10%) pom cov xim loj rov qab, 4 qhov txhab (20%) pom cov xim xim rov qab, thiab 2 qhov txhab (10%) pom tsis muaj kev txhim kho tseem ceeb.Kev rov qab los ntawm ob txhais ceg, hauv caug pob qij txha, ntsej muag thiab caj dab yog qhov pom tseeb tshaj plaws, thaum rov qab los ntawm cov extremities tsis zoo.
Nimtha et al.siv PRP ncua kev tshem tawm ntawm epidermal hlwb los npaj kev ncua thiab phosphate tsis ncua kev ncua ntawm cov hlwb epidermal los sib piv thiab saib xyuas lawv cov xim rov qab rau cov neeg mob uas muaj vitiligo ruaj khov.21 cov neeg mob vitiligo ruaj khov tau suav nrog thiab 42 qhov chaw dawb tau txais.Lub sijhawm ruaj khov ntawm vitiligo yog 4.5 xyoo.Cov neeg mob feem ntau pom qhov me me mus rau oval discrete pigment rov qab li 1-3 lub hlis tom qab kho.Thaum lub sij hawm 6 lub hlis ntawm kev soj ntsuam, qhov nruab nrab pigment rov qab yog 75.6% hauv PRP pawg thiab 65% hauv pawg tsis yog PRP.Qhov sib txawv ntawm thaj chaw pigment rov qab ntawm PRP pab pawg thiab tsis yog PRP pawg yog qhov tseem ceeb.PRP pab pawg tau pom cov xim zoo dua qub.Thaum txheeb xyuas cov xim rov qab los ntawm cov neeg mob uas muaj segmental vitiligo, tsis muaj qhov sib txawv tseem ceeb ntawm pawg PRP thiab pawg tsis yog PRP.
Kev siv PRP hauv Chloasma
Melasma yog ib hom kab mob ntawm daim tawv nqaij ntawm lub ntsej muag, uas feem ntau tshwm sim ntawm lub ntsej muag ntawm cov poj niam uas nquag raug ultraviolet lub teeb thiab muaj xim tawv nqaij sib sib zog nqus.Nws pathogenesis tsis tau qhia meej meej, thiab nws nyuaj rau kev kho thiab yooj yim rau rov zoo.Tam sim no, kev kho mob chloasma feem ntau siv txoj kev kho ua ke.Txawm hais tias kev txhaj tshuaj subcutaneous ntawm PRP muaj ntau txoj hauv kev kho mob chloasma, qhov ua tau zoo ntawm cov neeg mob tsis txaus siab, thiab nws yooj yim rau rov qab los tom qab tso tseg kev kho mob.Thiab cov tshuaj hauv qhov ncauj xws li tranexamic acid thiab glutathione tuaj yeem ua rau mob plab, kev coj khaub ncaws tsis zoo, mob taub hau, thiab txawm tias tsim cov hlab ntsha sib sib zog nqus.
Tshawb nrhiav kev kho tshiab rau chloasma yog ib qho tseem ceeb hauv kev tshawb fawb ntawm chloasma.Nws tau tshaj tawm tias PRP tuaj yeem txhim kho cov tawv nqaij ntawm cov neeg mob melasma.Cay ir rl i Et al.qhia tias ib tug poj niam 27 xyoo tau txais kev txhaj tshuaj subcutaneous microneedle ntawm PRP txhua 15 hnub.Thaum kawg ntawm qhov thib peb PRP kev kho mob, nws tau pom tias thaj tsam ntawm epidermal pigment rov qab yog> 80%, thiab tsis muaj rov tshwm sim hauv 6 lub hlis.Sirithanabadeekul et al.siv PRP rau kev kho mob chloasma kom ua tau zoo dua RCT, uas ntxiv tau lees paub qhov ua tau zoo ntawm kev txhaj tshuaj intracutaneous PRP rau kev kho mob chloasma.
Hofny et al.siv immunohistochemical txoj kev los ua TGF los ntawm subcutaneous microneedle txhaj PRP rau ntawm daim tawv nqaij mob ntawm cov neeg mob chloasma thiab ib txwm qhov chaw- β Kev sib piv ntawm cov protein qhia pom tias ua ntej PRP kev kho mob, daim tawv nqaij mob ntawm cov neeg mob chloasma thiab TGF nyob ib ncig ntawm daim tawv nqaij lesions- β Cov protein qhia tau qis dua li ntawm daim tawv nqaij noj qab haus huv (P<0.05).Tom qab PRP kev kho mob, TGF ntawm daim tawv nqaij mob nyob rau hauv cov neeg mob uas muaj chloasma- β Cov protein qhia tau nce ntau.Qhov tshwm sim no qhia tau hais tias kev txhim kho cov txiaj ntsig ntawm PRP ntawm cov neeg mob chloasma tuaj yeem ua tiav los ntawm kev nce TGF ntawm daim tawv nqaij qhov txhab- β Cov protein qhia ua tiav cov txiaj ntsig kho mob ntawm chloasma.
Photoelectric Technology Ua ke nrog Subcutaneous Txhaj Tshuaj PRP rau Kev Kho Mob Chloasma
Nrog rau kev txhim kho txuas ntxiv ntawm photoelectric thev naus laus zis, nws lub luag haujlwm hauv kev kho mob chloasma tau nyiam cov neeg tshawb nrhiav ntau dua.Tam sim no, cov lasers siv los kho chloasma suav nrog Q-hloov laser, lattice laser, khaus pulsed teeb, cuprous bromide laser thiab lwm yam kev kho mob ntsuas.Lub hauv paus ntsiab lus yog tias kev xaiv lub teeb blasting yog ua rau melanin hais nyob rau hauv lossis nruab nrab ntawm melanocytes los ntawm kev xaiv lub zog, thiab kev ua haujlwm ntawm melanocytes yog inactivated lossis inhibited los ntawm qis zog thiab ntau lub teeb blasting, thiab tib lub sijhawm, ntau lub teeb blasting ntawm melanin hais. yog nqa tawm, Nws tuaj yeem ua rau melanin hais me me thiab yooj yim dua rau kev nqos thiab tawm los ntawm lub cev.
Su Bifeng et al.kho chloasma nrog PRP dej lub teeb txhaj tshuaj ua ke nrog Q hloov Nd: YAG 1064nm laser.Ntawm 100 tus neeg mob chloasma, 15 tus neeg mob hauv pawg PRP + laser tau kho tau yooj yim, 22 tus neeg mob tau txais txiaj ntsig zoo, 11 tus neeg mob tau txhim kho, thiab 1 tus neeg mob tsis zoo;Hauv pab pawg laser ib leeg, 8 kis tau kho tau yooj yim, 21 kis tau zoo heev, 18 tus neeg tau txhim kho, thiab 3 kis tsis tau zoo.Qhov sib txawv ntawm ob pawg yog qhov tseem ceeb (P<0.05).Peng Guokai thiab Song Jiquan tau txheeb xyuas qhov ua tau zoo ntawm Q-hloov laser ua ke nrog PRP hauv kev kho mob ntawm lub ntsej muag chloasma.Cov txiaj ntsig tau pom tias Q-hloov laser ua ke nrog PRP tau zoo hauv kev kho mob ntawm lub ntsej muag chloasma
Raws li kev tshawb fawb tam sim no ntawm PRP hauv pigmented dermatoses, qhov ua tau ntawm PRP hauv kev kho mob chloasma yog tias PRP nce TGF ntawm daim tawv nqaij qhov txhab- β Cov protein qhia tuaj yeem txhim kho cov neeg mob melasma.Kev txhim kho ntawm PRP ntawm vitiligo cov neeg mob cov kab mob ntawm daim tawv nqaij tej zaum yuav muaj feem xyuam rau α Adhesion molecules secreted los ntawm granules muaj feem xyuam rau kev txhim kho ntawm lub zos microenvironment ntawm vitiligo lesions los ntawm cytokines.Qhov pib ntawm vitiligo yog ze ze rau kev tiv thaiv tsis zoo ntawm daim tawv nqaij.Cov kev tshawb fawb tau pom tias cov kab mob hauv lub cev tsis zoo ntawm cov neeg mob vitiligo muaj feem cuam tshuam nrog kev ua tsis tiav ntawm keratinocytes thiab melanocytes hauv daim tawv nqaij kom tiv thaiv kev puas tsuaj ntawm melanocytes los ntawm ntau yam inflammatory yam thiab chemokines tso tawm nyob rau hauv cov txheej txheem ntawm intracellular oxidative kev nyuaj siab.Txawm li cas los xij, ntau yam ntawm platelet loj hlob yam secreted los ntawm PRP thiab ntau yam tshuaj tiv thaiv cytokines tso tawm los ntawm platelets, xws li soluble qog necrosis factor receptor I, IL-4 thiab IL-10, uas yog antagonists ntawm interleukin-1 receptor, tej zaum yuav ua lub luag haujlwm qee yam hauv kev tswj hwm lub cev tiv thaiv kab mob hauv cheeb tsam ntawm daim tawv nqaij.
(Cov ntsiab lus ntawm tsab xov xwm no tau luam tawm dua, thiab peb tsis muab ib qho kev qhia lossis kev lees paub rau qhov raug, kev ntseeg tau lossis ua tiav ntawm cov ntsiab lus muaj nyob rau hauv tsab xov xwm no, thiab tsis muaj lub luag haujlwm rau cov kev xav ntawm tsab xov xwm no, thov nkag siab.)
Post lub sij hawm: Nov-24-2022