Daim ntawv thov kev kho mob thiab kev tshawb fawb ntawm PRP nyob rau hauv cov kab mob ntawm lub hauv caug pob qij txha
Platelet-nplua nuj plasma (PRP) yog plasma feem ntau ntawm platelets thiab cov qe ntshav dawb tau txais los ntawm centrifugation ntawm autologous peripheral ntshav.Ib tug loj tus naj npawb ntawm kev loj hlob yam thiab cytokines yog khaws cia nyob rau hauv lub α granules ntawm platelets.Thaum platelets tau qhib, lawv cov α granules tso tawm ntau yam kev loj hlob.Cov kev tshawb fawb tau pom tias cov cell loj hlob tuaj yeem txhawb kev sib txawv ntawm tes, kev loj hlob, extracellular matrix thiab collagen synthesis, yog li txhawb kev tsim thiab kho cov pob txha pob txha thiab ligament thiablwm yamcov ntaub so ntswg.Nyob rau tib lub sijhawm, nws tuaj yeem txhim kho cov lus teb inflammatory ntawm qhov chaw mob thiab txo cov tsos mob ntawm cov neeg mob.Ntxiv nrog rau cov txheej txheem loj hlob ntawm tes, PRP tseem muaj cov qe ntshav dawb ntau.Cov qe ntshav dawb thiab platelets tuaj yeem tso tawm ntau yam tshuaj tua kab mob peptides los khi rau cov kab mob, inhibit thiab tua cov kab mob, thiab ua lub luag haujlwm tiv thaiv kab mob.
PRP tau siv dav hauv kev kho mob orthopedics vim nws cov txheej txheem tsim khoom yooj yim, siv yooj yim thiab tus nqi qis, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm lub hauv caug kab mob hauv xyoo tas los.Kab lus no yuav tham txog kev kho mob thiab kev tshawb fawb ntawm platelet-nplua nuj plasma nyob rau hauv lub hauv caug osteoarthritis (KOA), meniscus raug mob, cruciate ligament raug mob, hauv caug synovitis thiab lwm yam kab mob hauv caug.
PRP daim ntawv thov technology
Lub unactivated PRP thiab activated PRP tso tawm yog kua thiab txhaj tshuaj, thiab lub unactivated PRP tuaj yeem tswj tau los ntawm kev ntxiv calcium chloride los yog thrombin los tswj lub sij hawm agglutination kom cov gel tuaj yeem tsim tom qab ncav cuag lub hom phiaj ntawm qhov chaw, thiaj li. ua tiav lub hom phiaj ntawm kev tso tawm ntawm kev loj hlob yam tseem ceeb.
PRP kev kho mob ntawm KOA
KOA yog ib qho kab mob hauv caug degenerative uas tshwm sim los ntawm kev puas tsuaj ntawm pob txha pob txha.Feem ntau ntawm cov neeg mob yog cov neeg laus thiab cov laus.Cov kev kho mob tshwm sim ntawm KOA yog mob hauv caug, o, thiab kev txwv kev ua si.Qhov kev tsis sib haum xeeb ntawm kev sib txuas thiab decomposition ntawm articular pob txha mos matrix yog lub hauv paus ntawm qhov tshwm sim ntawm KOA.Yog li ntawd, txhawb kev kho pob txha mos thiab tswj qhov sib npaug ntawm pob txha mos matrix yog tus yuam sij rau nws txoj kev kho.
Tam sim no, cov neeg mob KOA feem ntau yog tsim nyog rau kev kho mob.Lub hauv caug sib koom txhaj tshuaj ntawm hyaluronic acid, glucocorticoids thiab lwm yam tshuaj thiab qhov ncauj uas tsis yog-steroid anti-inflammatory tshuaj feem ntau yog siv rau kev kho mob.Nrog rau kev nkag siab ntawm kev tshawb fawb ntawm PRP los ntawm cov kws tshawb fawb hauv tsev thiab txawv teb chaws, kev kho mob ntawm KOA nrog PRP tau dhau los ua ntau thiab ntau dua nyob rau xyoo tas los no.
Mechanism ntawm kev ua:
1. Txhawb kev loj hlob ntawm chondrocytes:
Los ntawm kev ntsuas cov txiaj ntsig ntawm PRP ntawm kev muaj peev xwm ntawm luav chondrocytes, Wu J li al.pom tias PRP txhim kho qhov kev loj hlob ntawm chondrocytes, thiab xav tias PRP tuaj yeem tiv thaiv IL-1β-activated chondrocytes los ntawm inhibiting Wnt / β-catenin teeb liab transduction.
2. Inhibition ntawm chondrocyte inflammatory cov tshuaj tiv thaiv thiab degeneration:
Thaum qhib, PRP tso tawm ntau yam tshuaj tiv thaiv kab mob, xws li IL-1RA, TNF-Rⅰ, ⅱ, thiab lwm yam. tuaj yeem thaiv TNF-α ntsig txog kev taw qhia txoj hauv kev.
Kev kawm ua tau zoo:
Cov tsos mob tseem ceeb yog nyem qhov mob thiab txhim kho lub hauv caug ua haujlwm.
Lin KY et al.piv rau intra-articular txhaj ntawm LP-PRP nrog hyaluronic acid thiab ib txwm saline, thiab pom tias cov nyhuv curative ntawm thawj ob pawg yog zoo dua li ntawm cov saline ib txwm pab pawg neeg nyob rau hauv lub sij hawm luv luv, uas tau lees paub qhov kev kho mob nyhuv ntawm LP-PRP. thiab hyaluronic acid, thiab kev soj ntsuam mus sij hawm ntev (tom qab 1 xyoos) pom tias cov nyhuv ntawm LP-PRP zoo dua.Qee cov kev tshawb fawb tau ua ke nrog PRP nrog hyaluronic acid, thiab pom tias kev sib xyaw ntawm PRP thiab hyaluronic acid tsis tuaj yeem tsuas yog txo qhov mob thiab txhim kho kev ua haujlwm, tab sis kuj paub meej tias kev tsim kho pob txha pob txha los ntawm X-ray.
Txawm li cas los xij, Filardo G et al.ntseeg tias PRP pab pawg thiab pab pawg sodium hyaluronate tau ua haujlwm zoo hauv kev txhim kho lub hauv caug thiab cov tsos mob los ntawm kev tshawb nrhiav randomized, tab sis tsis pom qhov sib txawv tseem ceeb.Nws tau pom tias txoj kev ntawm PRP kev tswj hwm muaj qee yam cuam tshuam rau kev kho mob ntawm KOA.Du W et al.kho KOA nrog PRP intravarticular txhaj tshuaj thiab txhaj tshuaj extraarticular, thiab pom cov qhab nia VAS thiab Lysholm ua ntej noj tshuaj thiab 1 thiab 6 lub hlis tom qab noj tshuaj.Lawv pom tias ob txoj kev txhaj tshuaj tuaj yeem txhim kho VAS thiab Lysholm cov qhab nia nyob rau lub sijhawm luv, tab sis cov txiaj ntsig ntawm pawg txhaj tshuaj intra-articular zoo dua li pawg txhaj tshuaj extraarticular tom qab 6 lub hlis.Taniguchi Y et al.muab faib txoj kev tshawb no ntawm kev kho mob ntawm nruab nrab mus rau hnyav KOA rau hauv intraluminal txhaj tshuaj ua ke nrog intraluminal txhaj ntawm PRP pawg, intraluminal txhaj ntawm PRP pawg thiab intraluminal txhaj ntawm HA pawg.Txoj kev tshawb no qhia tau hais tias kev sib xyaw ntawm intraluminal txhaj ntawm PRP thiab intraluminal txhaj ntawm PRP yog zoo dua li intraluminal txhaj ntawm PRP lossis HA rau tsawg kawg yog 18 lub hlis hauv kev txhim kho VAS thiab WOMAC cov qhab nia.
(Cov ntsiab lus ntawm tsab xov xwm no tau luam tawm dua, thiab peb tsis muab ib qho kev qhia lossis kev lees paub rau qhov raug, kev ntseeg tau lossis ua tiav ntawm cov ntsiab lus muaj nyob rau hauv tsab xov xwm no, thiab tsis muaj lub luag haujlwm rau cov kev xav ntawm tsab xov xwm no, thov nkag siab.)
Post lub sij hawm: Nov-04-2022